Estradiol-sensitive vs estradiol-resistant patterns: why dose response differs

Two patients can take the same hormone dose and report opposite outcomes. Estradiol sensitivity is usually a receptor, route, and metabolism story, not a personality story. Here is how clinicians separate true sensitivity from under-dosing, conversion drift, and symptom misattribution.[4]

Estradiol response patterns differ even at identical doses.

Route kinetics often matter more than headline dose size.

Small, monitored adjustments beat aggressive swings.