Metformin for longevity: what we know and what remains uncertain

Metformin is often framed as a longevity shortcut, but evidence strength differs by population and endpoint. It has a clear role in glycemic management and possible preventive value in selected profiles, but it is not a universal anti-aging default. Here's the balanced evidence read.[2]

Metformin has strongest evidence in insulin-resistant and diabetic contexts.

Longevity claims in healthy populations remain less definitive.

Use requires monitoring and integration with behavior-first strategy.