SIGNAL // LOADING
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Semaglutide Injectable
RxWeight ManagementProvider reviewProvider Reviewed
Overview
The GLP-1 with ~14.9% mean weight loss at 68 weeks in STEP-1. Cleared through labs, intake, and provider review, paired with coaching that keeps it working past week four.
Key benefits
- 01~14.9% average weight loss at 68 weeks (STEP-1)
- 02~1.5-1.8% HbA1c reduction at max dose (SUSTAIN)
- 035-step titration with coaching dedicated to weeks 1-4
- 04Fiber, protein, and motility plan bundled with the Rx
Clinical rationale
Semaglutide is a GLP-1 receptor agonist. STEP-1 showed ~14.9% mean weight loss at 68 weeks on 2.4 mg weekly versus ~2.4% on placebo. SUSTAIN trials show 1.5-1.8% HbA1c reduction at max dose in T2D. Eligibility is thyroid history, pancreatitis status, pregnancy, and interactions with current Rx. Every intake clears a licensed provider before dispensing.
Directions
Begin with assessment and provider review. Treatment, dosing, and follow-up are determined by clinical eligibility.
Fit check
Who this is for
- BMI 30+, or 27+ with metabolic comorbidity (HbA1c 5.7-6.4%, hypertension, dyslipidemia)
- Prior tolerance to a GLP-1 - semaglutide is the right re-entry for members who did well on Wegovy or Ozempic
- Insurance coverage that lands on Wegovy/Ozempic rather than Zepbound
Who this isn't for
- Personal or family history of medullary thyroid carcinoma or MEN2
- Active pancreatitis, gastroparesis, or recent bariatric surgery
- Pregnancy, breastfeeding, or actively trying to conceive
- Short-term cosmetic cuts - the 3-6 month arc is where the data lives
Using it well
How to combine
- Fiber and 2.5-3.5 L water daily from week 1 to hold motility through titration
- Protein at 0.7-1.0 g per lb lean mass, plus creatine at 3-5 g/day
- Retest HbA1c, lipid panel, and liver function every 3-6 months on therapy
Safety considerations
- Slow titration is the single biggest lever on GI tolerance
- Breastfeeding guidance varies - raise it with your provider before refilling
- Escalate immediately for severe abdominal pain, uncontrolled vomiting, or gallbladder symptoms
Safety notes
- Prescription products require clinical eligibility and provider approval.
- Medication availability varies by state and clinical criteria.
Questions
What happens after assessment?
A licensed provider reviews your intake and labs. If semaglutide is a fit, they set titration and follow-up. If not, they route you to the right pathway - decline is a real outcome.Semaglutide or tirzepatide?
Tirzepatide has higher average weight loss; semaglutide has the longer post-market safety tail and clearer insurance pathways. See the compare guide for the full decision.Is compounded semaglutide the same as Ozempic?
No - compounded is not FDA-reviewed for efficacy and availability varies by state. We disclose sourcing upfront so you know exactly what you're taking.Can I switch between GLP-1s mid-treatment?
Yes with provider guidance. The usual move is a short washout plus a reset on titration. Coaching bridges the GI window so you don't lose the month.
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$299/mo
One-time
After provider review
$299
Pathway logistics
FormatPrescribed - oral or injection
FulfillmentAfter review, mail order
ReviewLicensed provider
EligibilityState-licensed
Note:Nothing ships until a licensed provider reviews your intake. If the pathway isn’t right, we say so.
Related reading
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