Glossary term

Lipoprotein(a)

Also known as Lp(a) - Lipoprotein little a

A genetically set risk multiplier. Over 50 mg/dL doubles heart-attack risk and doesn't respond to diet.

Lipoprotein(a), or Lp(a), is an LDL-like particle with an additional apolipoprotein attached. Your level is roughly 90% genetically determined and doesn't respond meaningfully to diet, statins, or exercise. Prevalence: about 1 in 5 adults sits over 50 mg/dL, which roughly doubles cardiovascular event risk. It's tested once as a lifetime read, then managed by hammering every other modifiable risk factor - ApoB under 60, blood pressure under 120/80, strict A1c under 5.5%. New siRNA drugs (pelacarsen, olpasiran) are in Phase 3. Included as a one-time add to the Advanced panel.

Symbol

Lp(a)

Unit

mg/dL

Typical range

Risk inflection ≥ 50 mg/dL (roughly doubles cardiovascular event risk).

Medically reviewed byDr. Lena Okafor, MD

Medical Director - updated April 2026 - How we review