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Glossary term
PDE5 inhibitor
Also known as Phosphodiesterase type 5 inhibitor
The drug class behind sildenafil and tadalafil. Augments the nitric oxide pathway for erectile function.
Phosphodiesterase type 5 inhibitors block PDE5 enzyme activity in smooth muscle, preserving cGMP and allowing the nitric oxide pathway to produce vasodilation in the corpus cavernosum. Response rates sit at 70-80% across trials for organic ED. The class includes sildenafil (short window), tadalafil (long window, daily option), vardenafil, and avanafil. Eligibility review covers nitrate use, cardiovascular status, and drug interactions.
Medically reviewed byDr. Lena Okafor, MD
Medical Director - updated April 2026How we review
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