Glossary term
Also known as Glucagon-like peptide-1 - GLP-1 receptor agonist - GLP-1 RA
A gut hormone your body makes after meals - and the drug class that mimics it to suppress appetite and lower A1c.
Glucagon-like peptide-1 (GLP-1) is released by L-cells in your small intestine after eating. It signals satiety, slows gastric emptying, and boosts insulin response to food. GLP-1 receptor agonists - semaglutide, tirzepatide, liraglutide - amplify that signal and are now the most-prescribed class for weight loss and type 2 diabetes. Trial data lands at ~15-21% average weight reduction over 68-72 weeks. Run the Advanced lab panel before any GLP-1 conversation; A1c, fasting insulin, and ApoB decide whether it's the right lever.
Medically reviewed byDr. Lena Okafor, MD
Medical Director - updated April 2026How we review
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